A naturally produced signaling molecule combats chronic and resistant hard-to-treat infections and contaminations by inducing microbial biofilms to disperse.
Background
Bacterial biofilms, or complex organized communities of bacterial cells, are responsible for most chronic infections, as well as for major medical contaminations and industrial biofouling. Bacteria in biofilms are resistant to conventional antimicrobial treatments and are notoriously difficult to eradicate, leading to persistent infections or recalcitrant sources of contamination. Biofilm-specific strategies are needed to address these major unmet medical and industrial issues.
Technology Overview
Cis-2-decenoic acid (cis-DA) is a naturally produced bacterial signaling molecule that combats chronic and resistant hard-to-treat infections and contaminations via a biofilm-specific mechanism of action. Binghamton University researchers have found that by inducing microbial biofilms to disperse or disaggregate, cis-DA abrogates their inherent defense mechanisms, making the microorganisms more susceptible to antimicrobial agents. Acting at nanomolar concentrations, cis-DA has been shown to act as a robust adjunctive to enhance the efficacy of various medical antimicrobials and industrial disinfectants against a wide array of gram-positive and gram-negative bacteria, as well as a number of fungal pathogens.
Benefits
Applications
Applications include, but are not limited to:
The best public university in the Northeast.
A world-class institution, Binghamton University offers students a broad, interdisciplinary education with an international perspective and one of the most vibrant research programs in the nation.
Ranked among the elite public universities in the country, Binghamton challenges students academically, not financially, in its unique, best-of-both-worlds environment.
Our academic culture rivals a first-rate private university — rigorous, collaborative and boldly innovative — while our campus culture exemplifies the best kind of public university experience: richly diverse students, active social life and deep engagement with the community.
Our students, both undergraduate and graduate, work one-on-one with an exceptional faculty and groundbreaking scholars. They take advantage of special academic opportunities like combined degrees, foreign language study groups and an unparalleled international education program.
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